• MicroRNA Regulation of Stem Cell Fate
  We study how microRNAs control the molecular and signaling pathways that guide the development and behavior of human hematopoietic stem and progenitor cells. By dissecting these regulatory networks, we aim to better understand how cellular identity and function are maintained—or disrupted—in leukemia.

• Origins of Pediatric and Adult Leukemia
  We seek to define the developmental, cellular, and molecular origins of leukemia across age groups, with a focus on how stem-like properties contribute to disease onset and progression. Our work includes the study of Down syndrome-associated leukemia and other high-risk pediatric leukemias.

To pursue these questions, we use a multi-disciplinary approach that integrates multi-omic profiling of primary patient samples with functional genomics and in vivo xenotransplantation models in immunodeficient mice. This platform allows us to connect molecular signatures with biological function and therapeutic response, with the ultimate goal of identifying new targets for precision medicine.

Our lab is based at the Hillman Cancer Center in Pittsburgh, PA, and is part of the University of Pittsburgh’s vibrant community of cancer and stem cell researchers. We are committed to advancing science that directly informs better diagnostics, treatments, and outcomes for patients with leukemia.