LECHMAN LAB

WE’RE A hematology-oncology lab dedicated to real-life solutions

The Lechman Lab, based at the Hillman Cancer Center in Pittsburgh, PA, investigates blood development and leukemia with a focus on stem cells, pediatric cancers, and Down syndrome-associated AML.

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Recent publications

Explore our latest work on blood development, leukemia stem cells, and pediatric AML, highlighting our ongoing efforts to advance cancer research.

KDM6 demethylases integrate DNA repair gene regulation and loss of KDM6A sensitizes human acute myeloid leukemia to PARP and BCL2 inhibition. 

PLAG1 dampens protein synthesis to promote human hematopoietic stem cell self-renewal. 

Identification of the global miR-130a targetome reveals a role for TBL1XR1 in hematopoietic stem cell self-renewal and t(8;21) AML. 

More Publications
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Pittsburgh Pa

UPMC Hillman Cancer Center
Research Pavilion
Suite 1.46D
5117 Centre Avenue